Poisoned Lottery Winner's Kin Were Suspicious

Urooj Khan had just brought home his $425,000 lottery check when he unexpectedly died the following day. Now, certain members of Khan's family are speaking publicly about the mystery -- and his nephew told ABC News they knew something was not right.

"He was a healthy guy, you know?" said the nephew, Minhaj Khan said. "He worked so hard. He was always going about his business and, the thing is: After he won the lottery and the next day later he passes away -- it's awkward. It raises some eyebrows."

The medical examiner initially ruled Urooj Khan, 46, an immigrant from India who owned dry-cleaning businesses in Chicago, died July 20, 2012, of natural causes. But after a family member demanded more tests, authorities in November found a lethal amount of cyanide in his blood, turning the case into a homicide investigation.

"When we found out there was cyanide in his blood after the extensive toxicology reports, we had to believe that ... somebody had to kill him," Minhaj Khan said. "It had to happen, because where can you get cyanide?"

In Photos: Biggest Lotto Jackpot Winners

Authorities could be one step closer to learning what happened to Urooj Khan. A judge Friday approved an order to exhume his body at Rosehill Cemetery in Chicago as early as Thursday to perform further tests.

Lottery Winner Murdered: Widow Questioned By Police Watch Video

Moments after the court hearing, Urooj Khan's sister, Meraj Khan, remembered her brother as the kind of person who would've shared his jackpot with anyone. Speaking at the Cook County Courthouse, she hoped the exhumation would help the investigation.

"It's very hard because I wanted my brother to rest in peace, but then we have to have justice served," she said, according to ABC News station WLS in Chicago. "So if that's what it takes for him to bring justice and peace, then that's what needs to be done."

Khan reportedly did not have a will. With the investigation moving forward, his family is waging a legal fight against his widow, Shabana Ansari, 32, over more than $1 million, including Urooj Khan's lottery winnings, as well as his business and real estate holdings.

Khan's brother filed a petition Wednesday to a judge asking Citibank to release information about Khan's assets to "ultimately ensure" that [Khan's] minor daughter from a prior marriage "receives her proper share."

Ansari may have tried to cash the jackpot check after Khan's death, according to court documents, which also showed Urooj Khan's family is questioning if the couple was ever even legally married.

Ansari, Urooj Khan's second wife, who still works at the couple's dry cleaning business, has insisted they were married legally.

She has told reporters the night before her husband died, she cooked a traditional Indian meal for him and their family, including Khan's daughter and Ansari's father. Not feeling well, Khan retired early, Ansari told the Chicago Sun-Times, falling asleep in a chair, waking up in agony, then collapsing in the middle of the night. She said she called 911.

"It has been an incredibly hard time," she told ABC News earlier this week. "We went from being the happiest the day we got the check. It was the best sleep I've had. And then the next day, everything was gone.

"I am cooperating with the investigation," Ansari told ABC News. "I want the truth to come out."

Ansari has not been named a suspect, but her attorney, Steven Kozicki, said investigators did question her for more than four hours.

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Syria rebels seize base as envoy holds talks

BEIRUT/GENEVA (Reuters) - Rebels seized control of one of Syria's largest helicopter bases on Friday, opposition sources said, in their first capture of a military airfield used by President Bashar al-Assad's forces.

Fighting raged across the country as international mediator Lakhdar Brahimi sought a political solution to Syria's civil war, meeting senior U.S. and Russian officials in Geneva.

But the two world powers are still deadlocked over Assad's fate in any transition.

The United States, which backs the 21-month-old revolt, says Assad can play no future role, while Syria's main arms supplier Russia said before the talks that his exit should not be a precondition for negotiations.

Syria is mired in bloodshed that has cost more than 60,000 lives and displaced millions of people. Severe winter weather is compounding their misery. The U.N. children's agency UNICEF says more than 2 million children are struggling to stay warm.

The capture of Taftanaz air base, after months of sporadic fighting, could help rebels solidify their hold on northern Syria, according to Rami Abdelrahman, head of the pro-opposition Syrian Observatory for Human Rights.

TACTICAL, NOT STRATEGIC GAIN

But Yezid Sayigh, at the Carnegie Middle East Centre in Beirut, said it was not a game-changer, noting that it had taken months for the rebels to overrun a base whose usefulness to the military was already compromised by the clashes around it.

"This is a tactical rather than a strategic gain," he said.

In Geneva, U.N.-Arab League envoy Brahimi's closed-door talks began with individual meetings with U.S. Deputy Secretary of State William Burns and Russian Deputy Foreign Minister Mikhail Bogdanov. He later held talks with both sides together.

A U.S. official said negotiations would focus on "creating the conditions to advance a political solution - specifically a transitional governing body".

Six months ago, world powers meeting in Geneva proposed a transitional government but left open Assad's role. Brahimi told Reuters on Wednesday that the Syrian leader could play no part in such a transition and suggested it was time he quit.

Responding a day later, Syria's foreign ministry berated the veteran Algerian diplomat as "flagrantly biased toward those who are conspiring against Syria and its people".

Russia has argued that outside powers should not decide who should take part in any transitional government.

"Only the Syrians themselves can agree on a model or the further development of their country," Foreign Ministry spokesman Alexander Lukashevich said.

REFUGEE MISERY

But Syrians seem too divided for any such agreement.

The umbrella opposition group abroad, the Syrian National Coalition, said on Friday it had proposed a transition plan that would kept government institutions intact at a meeting with diplomats in London this week. But the plan has received no public endorsement from the opposition's foreign backers.

With no end to fighting in sight, the misery of Syrian civilians has rapidly increased, especially with the advent of some of the worst winter conditions in years.

Saudi Arabia said it would send $10 million worth of aid to help Syrian refugees in Jordan, where torrential rain has flooded hundreds of tents in the Zaatari refugee camp.

A fierce storm that swept the region has raised concerns for 600,000 Syrian refugees who have fled to neighboring countries, as well as more than 2.5 million displaced inside Syria, many of whom live in flimsy tents at unofficial border camps.

Opposition activists report dozens of weather-related deaths in Syria in the last four days. UNICEF said refugee children are at risk because conditions have hampered access to services.

Earlier this week, another United Nations agency said around one million Syrians were going hungry. The World Food Programme cited difficulties entering conflict zones and said that the few government-approved aid agencies allowed to distribute aid were stretched to the limit.

The WFP said it supplying rations to about 1.5 million people in Syria each month, far short of the 2.5 million deemed to be in need.

(Additional reporting by Alexander Dzsiadosz in Beirut and Raissa Kasolowsky in Abu Dhabi; Editing by Alistair Lyon)

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Chinese shipping companies switching to RMB for transactions

SINGAPORE: More Chinese shipping companies are asking for renminbi (RMB) to be used as the settlement currency for shipping freight rates.

The shipping sector is seeing growing usage of the Chinese currency.

To help Chinese shippers manage their exposure, major shipping broker, Freight Investor Services, has even launched a freight derivative in Chinese Yuan last month.

A forward freight agreement (FFA) allows ship owners, charterers and speculators to hedge against the volatility of freight rates.

It gives contract owners the right to buy and sell the price of freight for future dates.

FFAs are built on an index composed of a shipping route for tanker (ship) or a basket of routes for dry bulk, contracts are traded "over the counter" on a principal-to-principal basis and can be cleared through a clearing house.

International settlements in renminbi have been on the rise.

Beijing has been promoting the wider use of its currency globally through bilateral currency swaps and trade settlement deals.

Global transaction services organisation SWIFT noted a 24 per cent surge in yuan settlement in November 2012 as compared to a month before.

Shipowners like First Ship Lease Trust Management said it is a natural development for charter rates to shift from US dollars to renminbi as a significant volume of goods being transported is also priced in Chinese Yuan.

Guy Broadley, director at Freight Investor Services said: "China's involvement in the commodity story over the last 10 years is obviously been very great... last year, China's dry bulk commodity imports were equivalent to about 44 per cent of global seaborne trade. We feel that it is important for Chinese traders to be able to hedge that price risk by having a RMB-denominated contract."

But shipping analysts believe this trend is limited to small and medium-sized Chinese shipping companies, which transact the bulk of their trades domestically.

Jayendu Krishna, senior manager at Drewry said: "China has a lot of restrictions in terms of foreign currencies and because of the restrictions they are not really able to trade in what exists today is the US-denominated transactions. So, with the introduction of this RMB-denominated FFA, probably more Chinese players will be interested because they are able to hedge against the risk of the freight volatility."

Currently, most shipping chartering is settled in US dollars.

Shekaran Krishnan, partner at Ernst & Young said: "It would make a lot of sense for them to have the revenue which is the freight revenue in local RMB because it is a natural arbitrage against the cost they have to pay locally and if they have it in local currency, they can avoid the currency fluctuation that they are exposed to."

Given the limited supply of the Chinese yuan, analysts do not see the renminbi replacing the US dollar anytime soon, as the shipping industry is still very much a US dollar-dominated business.

- CNA/xq

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We only fired back, India tells Pak as LoC remains tense

JAMMU/NEW DELHI: Pakistani troops fired at Indian posts in Jammu and Kashmir again on Friday, leading to an exchange of fire between Indian and Pakistani army across the Line of Control (LoC).

Army sources said Pakistan opened fire at posts close to the Line of Control (LoC) in the Krishna Ghati sector, around 250 km from here, in the afternoon.

"The Army offered a calibrated response to silence Pakistani guns," said the source. The firing lasted for half an hour.

"There were no casualties on this (Indian) side," the source said.

Pakistan has been firing on Indian positions daily violating a ceasefire agreement after its troops killed two Indian soldiers near LoC on Tuesday.

We only fired back, India tells Pakistan

The Indian envoy told the Pakistan government on Friday that the Indian Army gave a "controlled response" to "unprovoked" firing by Pakistani troops along the Jammu and Kashmir border.

Indian high commissioner Sharat Sabharwal conveyed this to Pakistan foreign secretary Jalil Abbas Jilani in Islamabad, the external affairs ministry spokesman said here.

Sabharwal was on Friday served a "note verbale" after Pakistan alleged that Indian firing and shelling along the Line of Control (LoC) in Kashmir killed a Pakistani soldier.

"As we understand it, there has been unprovoked firing by Pakistan in the Mandher sector and there was controlled response from our side," the spokesman said.

The Indian high commissioner also told the Pakistanis that the sanctity of the LoC "is the most important confidence building measure between India and Pakistan".

The two countries agreed to a ceasefire along the winding LoC, which divides Kashmir between India and Pakistan, in 2003. The truce has largely held on in the past decade.

The spokesman also reiterated India's refusal to involve any third party to probe the allegations and counter allegations from the two countries on the LoC.

India and Pakistan "have a mechanism to bilaterally solve such issues", the official said.

He said the Director Generals Military Operation of both countries were in contact. "We are fully capable of handling all these matters without involving the UN or any other third party."

Tensions between India and Pakistan have escalated in Kashmir since January 6 when a Pakistani solider was killed allegedly by Indian troops.

Two days later, two Indian soldiers were killed and beheaded near the LoC. Indian officials blamed Pakistani troops for the horror.

India summoned the Pakistani envoy on Thursday to lodge a strong protest.

The spokesman added that New Delhi and Islamabad were also discussing Pakistan's decision to prevent trucks from Jammu and Kashmir from entering Pakistani Kashmir.

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Lung cancer scans backed for older, heavy smokers

The American Cancer Society says there now is enough evidence to recommend screening certain older, heavy smokers for lung cancer.

The society is releasing new guidelines Friday for annual CT lung scans. But they are only recommended for people ages 55 to 74 who have smoked a pack of cigarettes a day for 30 years or the equivalent, such as two packs a day for 15 years. Research shows that screening these people can cut the risk of dying of lung cancer by 20 percent.

Whether screening would help others is not known, so scans are not recommended for them.

Before patients decide whether to be screened, the guidelines say they should have a frank talk about risks and benefits with their doctors.

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Teen to Hero Teacher: 'I Don't Want to Shoot You'

A California teacher'sbrave conversation with a 16-year-old gunman who had opened fire on his classroom bullies allowed 28 other students to quickly escape what could have been a massacre.

Science teacher Ryan Heber calmly confronted the teenager after he shot and critically wounded a classmate, whom authorities say had bullied the boy for more than year at Taft Union High School.

"I don't want to shoot you," the teen gunman told Heber, who convinced the teen gunman to drop his weapon, a high power shotgun.

Responding to calls of shots fired, campus supervisor Kim Lee Fields arrived at the classroom and helped Heber talk the boy into giving up the weapon.

"This teacher and this counselor stood there face-to-face not knowing if he was going to shoot them," said Kern County Sheriff Donny Youngblood. "They probably expected the worst and hoped for the best, but they gave the students a chance to escape."

One student, who police say the shooter had targeted, was shot. He was airlifted to a hospital and remains in critical, but stable condition, Youngblood said. He is expected to undergo surgery today.

Two other students received minor injuries. One suffered hearing loss and another fell over a table while evacuating. Heber received a wound to his head from a stray pellet, police said.

Taft Midway Driller/Doug Keeler/AP Photo

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Police said the teen, whose name has not been made public because he is a minor, began plotting on Wednesday night to kill two students he felt had bullied him.

Authorities believe the suspect found his older brother's gun and brought it into the just before 9 a.m. on Thursday and went to Heber's second-floor classroom where a first period science class with 20 students was taking place.

"He planned the event," Youngblood said. "Certainly he believed that the two people he targeted had bullied him, in his mind. Whether that occurred or not we don't know yet."

The gunman entered the classroom and shot one of his classmates. Heber immediately began trying to talk him into handing over the gun, and evacuating the other students through the classroom's backdoor.

"The heroics of these two people goes without saying. ... They could have just as easily ... tried to get out of the classroom and left students, and they didn't," the sheriff said. "They knew not to let him leave the classroom with that shotgun."

The gunman was found with several rounds of additional ammunition in his pockets.

Within one minute of the shooting, a 911 call was placed and police arrived on the scene. An announcement was made placing the school on lockdown and warning teachers and students that the precautions were "not a drill."

The school had recently announced new safety procedures following last month's deadly shooting at a Newtown, Conn., elementary school in which 20 young children were killed. Six school staffers, including the principal, were killed as they tried to protect the children from gunman Adam Lanza.

The school employs an armed security guard, but he was not on campus Thursday morning.

Youngblood said the student would be charged with attempted murder, but the district attorney would decide if he was to be tried as an adult.

Some 900 students attend Taft Union High School, located in Taft, Calif., a rural community in southern California.

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Syria denounces peace envoy who hinted Assad must go

BEIRUT (Reuters) - Syria denounced international envoy Lakhdar Brahimi as "flagrantly biased" on Thursday, casting doubt on how long the U.N.-Arab League mediator can pursue his peace mission.

The Syrian Foreign Ministry was responding to remarks by Brahimi a day earlier in which he ruled out a role for President Bashar al-Assad in a transitional government and effectively called for the Baathist leader to quit.

"In Syria...what people are saying is that a family ruling for 40 years is a little bit too long," Brahimi told the BBC, referring to Assad, who inherited his post from his father Hafez al-Assad, who seized power in 1970 and ruled for 30 years.

"President Assad could take the lead in responding to the aspiration of his people rather than resisting it," the veteran Algerian diplomat said, hinting the Syrian leader should go.

The Foreign Ministry in Damascus said it was very surprised at Brahimi's comments, which showed "he is flagrantly biased for those who are conspiring against Syria and its people".

Brahimi has had no more success than his predecessor Kofi Annan in his quest for a political solution to a 21-month-old conflict in which more than 60,000 people have been killed.

British Foreign Secretary William Hague warned that violence in Syria might worsen and said the international community must "step up" its response if it does.

So far regional rivalries and divisions among big powers have stymied any concerted approach to the upheaval, one of the bloodiest to emerge from a series of revolts in the Arab world.

Russian and U.S. diplomats, who back opposing sides of the war, will meet Brahimi in Geneva on Friday.

"MASK OF IMPARTIALITY"

Syria's al-Watan newspaper daily said Brahimi had removed his "mask of impartiality" to reveal his true face as a "a tool for the implementation of the policy of some Western countries".

On Sunday Assad, making his first public speech in six months, offered no concessions and he said he would never talk to foes he branded terrorists and Western puppets.

As peace efforts floundered, rebels battled for a strategic air base for a second day, pursuing a civil war that had briefly receded for some Damascus residents who set aside their differences to play in a rare snowfall that blanketed the city.

For a few hours, people in the capital dropped their weapons for snowballs and traded hatred for giggles.

"Last night, for the first time in months, I heard laughter instead of shelling. Even the security forces put down their guns and helped us make a snowman," Iman, a resident of the central Shaalan neighborhood, said by Skype.

There was no respite on other battlefronts, with heavy fighting around the Taftanaz base in northwestern Syria, which insurgents are trying to capture to extend their grip on Idlib province and weaken Assad's control of the skies.

Rebels assaulted the airport's main buildings and armory using heavy guns, tanks and other weapons and appeared to have overrun half the area of the base, said Rami Abdelrahman, director of the Syrian Observatory for Human Rights, a pro-opposition group that monitors the conflict from abroad.

"Now, it's serious," he said.

The air base has been used to launch helicopter attacks in the region, and its loss would be a blow to the government's ability to defend its positions there, Abdelrahman said.

MISSILE LAUNCH

Insurgents have tried to take the base for months, but have been bolstered by the recent arrival of Islamist fighters including the al Qaeda-linked al-Nusra Front, he added.

There was no immediate government account of the fighting, which could not be confirmed independently.

Opposition forces have seized swathes of territory in northern Syria in recent months, but remain vulnerable to attack by the military's planes and helicopters - hence their strategy of trying to capture air bases such as the one at Taftanaz.

There was no word on whether the firing of a short-range ballistic missile inside Syria on Wednesday, reported by a NATO official, was linked to the fighting at Taftanaz.

NATO could not confirm the type of missile used, but the description fit the Scuds that are in the Syrian military's armory, the official added, describing the latest launch and similar ones last week as "reckless".

A NATO official said that since the start of December 2012, the alliance had detected at least 15 launches of unguided, short-range ballistic missile inside Syria.

Neither side has gained a clear military advantage in the war pitting mostly Sunni Muslim rebels against security forces dominated by Assad's minority, Shi'ite-linked Alawite sect.

The Observatory also reported fighting between rebels and troops in the Sayyida Zeinab area of Damascus, and air raids were reported in the capital's Maleiha area and eastern suburbs.

Despite some support from Sunni regional powers including Turkey, Saudi Arabia and Qatar, the rebels remain largely disorganized, fragmented and ill-equipped. Poor discipline, looting and insecurity in some insurgent-held areas have also eroded their support from civilians.

Gloom has gripped Damascus for months, as the rebellion edges closer to the capital, but the snowfall offered a rare break from gunfire and shelling echoing from its outskirts.

"We felt a smile that has been missing from our faces for almost two years and we were all just Syrians," said Amin, a resident of central Damascus, speaking on the internet.

"For a few hours our hearts were as pure as the snow."

(Additional reporting by Oliver Holmes and Erika Solomon in Beirut and Mohammed Abbas in London; Editing by Alistair Lyon)

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Football: Adebayor included as Africa Cup squads named

JOHANNESBURG: Emmanuel Adebayor will play at the 2013 Africa Cup of Nations after he was included in Togo's squad as the 16 sides finalised their 23-man squads.

Mahamadou Diarra will meanwhile miss the tournament, and a late-minute change left Brown Ideye thrilled and Nigeria team-mate Raheem Lawal devastated.

It was all part of the drama ahead of the January 19-February 10 tournament that will be played in five South African cities.

Tottenham striker and Togo captain Adebayor said last year he would shun the competition, citing security concerns after being part of the squad attacked in Angola ahead of the 2010 finals.

A player and an official were killed by separatists seeking independence for the oil-rich Cabinda enclave and Adebayor escaped injury by cowering under a bus seat.

As Tottenham, the Togo president and national football officials became involved in the saga, Adebayor refused to reveal his plans, and his inclusion became official only when the 23-man squad was named by coach Didier Six.

Perennial underachievers Togo are in the Rustenburg-based 'group of death' with title favourites Ivory Coast and other former champions Algeria and Tunisia and are given little hope of survival.

Mali, third last year and considered likely quarter-finalists after being drawn with the Democratic Republic of Congo, Ghana and Niger, suffered a late setback when Fulham midfielder Diarra pulled out injured.

A recurring knee injury failed to heal, meaning the veteran will miss a second consecutive Cup of Nations, although the blow was cushioned by the return of another experienced midfielder, Mohamed Lamine Sissoko.

Turkey-based midfielder Lawal was included in a Nigerian squad leaked to the media a day before the final-squad deadline, only to be replaced by striker Ideye when it was officially announced.

Home-based players have traditionally been ignored by Super Eagles coaches, but Stephen Keshi has chosen six, including goalkeeper Chigozie Agbim and strikers Sunday Mba and Ejike Uzoenyi from Enugu Rangers.

Shock absentees from the 2012 tournament, Nigeria face defending champions Zambia and outsiders Burkina Faso and Ethiopia in Group C and are expected to make the knock-out phase at least.

Debutants Cape Verde made a couple of last-minute changes with injured midfielder Odair Fortes and unavailable striker Ze Luis replaced by Portugal-based pair Platini and Rambe.

Cape Verde face hosts South Africa in the January 19 opening fixture at the 90,000-seat Soccer City stadium in Soweto and also confront former champions Morocco and Angola in the first round.

- AFP/de

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Cold wave claims 23 more lives in north India

NEW DELHI: At least 23 people lost their lives due to cold wave in Uttar Pradesh and Uttarakhand even as temperature in parts of north India soared, a trend that weatherman said will persist.

People in the national capital today woke up to a pleasant morning as the minimum temperature rose more than a degree from yesterday to settle at 5.8 degrees Celsius.

Delhi has been witnessing cold wave conditions for the past one week with both minimum and maximum remaining five degrees below normal, but there has been a welcome respite since yesterday.

"The temperature will rise in the coming days," the Met said.

However, in the plains of Uttar Pradesh, the biting cold wave conditions snuffed out 16 more lives during the last 24 hours as death toll due to the harsh weather touched 249 this winter.

Five persons died in Gorakhpur district which was the coldest place in the state yesterday, followed by four each in Farrukhabad and Barabanki, two in Sant Kabirnagar and one in Bijnore.

Met office said that Lucknow along with Najibabad in Bijnore were coldest in the state recording 0.5 (-6) degrees Celsius followed by Kheri with 1 deg C, Sultanpur 1.2 (-7) deg C and Gorakhpur 1.8 (-7) deg C.

In Uttarakhand, seven persons died due to cold wave even as temperature soared in most parts of the hill state giving respite to people.

All the casualties were reported from Roorkee and Haridwar districts where icy northwesterly winds continued to blow amid dense fog.

Mercury rose marginally in most places with Dehradun recording a minimum of 3.5 deg C, Pantnagar 0.2 deg C, Mukteshwar 0.2 deg C, Tehri 1.0 Pithoragarh 2.3 and Nainital 4.0 degree C, the MeT office said.

"The rising temperature at most places shows that the downtrend has finally come to an end," a MeT official said adding it was a pointer towards more pleasant days ahead.

Cold wave sweeps Jharkhand

Chilly conditions prevailed in Jharkhand with Kanke on the outskirts of Ranchi recording a minimum of 3.4 degree Celsius and Ranchi's low temperature being 8 degree Celsius today.

"Freezing conditions in North-Western areas of the country and chilly winds have brought down temperatures," an official with Meteorological department said here.

The minimum temperatures recorded in Jamshedpur and Palamau are 5.1 degree and 6.4 degree Celsius respectively, the sources said adding chill also prevailed in other parts of the state.

The minimum temperature in Kanke, which recorded zero degree Celsius yesterday for the second time this winter, improved with the mercury recording 3.4 degree Celsius, A Wadood, a Weather Scientist with Birsa Agriculture University here said.

The maximum temperatures at many places, however, remained about 20 degree Celsius, sources said.

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Retooling Pap test to spot more kinds of cancer

WASHINGTON (AP) — For years, doctors have lamented that there's no Pap test for deadly ovarian cancer. Wednesday, scientists reported encouraging signs that one day, there might be.

Researchers are trying to retool the Pap, a test for cervical cancer that millions of women get, so that it could spot early signs of other gynecologic cancers, too.

How? It turns out that cells can flake off of tumors in the ovaries or the lining of the uterus, and float down to rest in the cervix, where Pap tests are performed. These cells are too rare to recognize under the microscope. But researchers from Johns Hopkins University used some sophisticated DNA testing on the Pap samples to uncover the evidence — gene mutations that show cancer is present.

In a pilot study, they analyzed Pap smears from 46 women who already were diagnosed with either ovarian or endometrial cancer. The new technique found all the endometrial cancers and 41 percent of the ovarian tumors, the team reported Wednesday in the journal Science Translational Medicine.

This is very early-stage research, and women shouldn't expect any change in their routine Paps. It will take years of additional testing to prove if the so-called PapGene technique really could work as a screening tool, used to spot cancer in women who thought they were healthy.

"Now the hard work begins," said Hopkins oncologist Dr. Luis Diaz, whose team is collecting hundreds of additional Pap samples for more study and is exploring ways to enhance the detection of ovarian cancer.

But if it ultimately pans out, "the neat part about this is, the patient won't feel anything different," and the Pap wouldn't be performed differently, Diaz added. The extra work would come in a lab.

The gene-based technique marks a new approach toward cancer screening, and specialists are watching closely.

"This is very encouraging, and it shows great potential," said American Cancer Society genetics expert Michael Melner.

"We are a long way from being able to see any impact on our patients," cautioned Dr. Shannon Westin of the University of Texas MD Anderson Cancer Center. She reviewed the research in an accompanying editorial, and said the ovarian cancer detection would need improvement if the test is to work.

But she noted that ovarian cancer has poor survival rates because it's rarely caught early. "If this screening test could identify ovarian cancer at an early stage, there would be a profound impact on patient outcomes and mortality," Westin said.

More than 22,000 U.S. women are diagnosed with ovarian cancer each year, and more than 15,000 die. Symptoms such as pain and bloating seldom are obvious until the cancer is more advanced, and numerous attempts at screening tests have failed.

Endometrial cancer affects about 47,000 women a year, and kills about 8,000. There is no screening test for it either, but most women are diagnosed early because of postmenopausal bleeding.

The Hopkins research piggybacks on one of the most successful cancer screening tools, the Pap, and a newer technology used along with it. With a standard Pap, a little brush scrapes off cells from the cervix, which are stored in a vial to examine for signs of cervical cancer. Today, many women's Paps undergo an additional DNA-based test to see if they harbor the HPV virus, which can spur cervical cancer.

So the Hopkins team, funded largely by cancer advocacy groups, decided to look for DNA evidence of other gynecologic tumors. It developed a method to rapidly screen the Pap samples for those mutations using standard genetics equipment that Diaz said wouldn't add much to the cost of a Pap-plus-HPV test. He said the technique could detect both early-stage and more advanced tumors. Importantly, tests of Paps from 14 healthy women turned up no false alarms.

The endometrial cancers may have been easier to find because cells from those tumors don't have as far to travel as ovarian cancer cells, Diaz said. Researchers will study whether inserting the Pap brush deeper, testing during different times of the menstrual cycle, or other factors might improve detection of ovarian cancer.

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