Missing Woman Survived on Tomatoes and Snow

The woman who was stranded in the Sierra Nevada mountains survived for six days by eating tomatoes and snow until she was found by her brother, who was part of a team searching for her and her boyfriend.

Paula Lane, 46, was rescued Wednesday. Her boyfriend, Roderick Clifton, died.

He had left her to find help after their Jeep got stuck in the snow as they drove from Clifton's mother's home in Citrus Heights, Calif., to their own home in Gardnerville, Nev., Nov. 29.

They were reported missing the following day after Lane failed to meet her mother for a planned dinner and wasn't reachable by cellphone, according to KXTV, an ABC TV affiliate in Sacramento.

The couple are believed to have taken their Jeep Cherokee off-roading when they became stuck off Highways 88-89 in Alpine County.

The area where they got stuck was so remote that cellphone service was limited. The couple were unable to call for help, and police couldn't locate them using their cellphones.

Clifton, 44, never returned to Lane. His body was found Wednesday, several miles from the highway. Police have not yet confirmed how he died, but they don't believe foul play was involved.

Citrus Heights Police Dept.

Missing Nevada Couple Found, Boyfriend Dead Watch Video

Lane had set out to find help after her boyfriend failed to return.

Lane's family is happy she is alive.

"It's been a rough haul, waiting all those days, trying to know if she'd made it or not," Lane's older sister, Linda Hathaway, said at a news conference Thursday at Carson Tahoe Regional Hospital, the Carson City, Nev., facility to which Lane was taken and treated for first-degree frostbite and malnourishment.

Police had launched a manhunt for the missing couple, but bad weather at times prevented authorities from sending up planes or helicopters.

Hathaway had given up hope, and said she had prepared her sister's 11-year-old twin sons for the worst.
"We sat them down to tell them that their mother may not come back," she said.

But the women's brother kept searching along the route that Lane would have taken home. Lane and Clifton routinely made the drive from Citrus Heights to Gardnerville.

Hathaway said her brother eventually found Lane crawling along Highway 88.

"I took the call and to hear him say, 'I found her, I found her,'" Hathaway said.

When she was reunited with her sister, Hathaway recalled: "I gave her the biggest kiss that I could without hurting her."

Hathaway described her sister as tenacious.

"I tell you, my sister may be little, but she is mighty and she's a survivor and loves life," she added.

Dr. Vijay Maiya, Lane's physician, said his patient had apparently found shelter by "hiding out in a hollow tree," in addition to eating the tomatoes they had with them.

"She is medically stable. She's recovering nicely," Maiya said at the news conference, adding that 25 percent of Lane's recovery would be physical and 75 percent would be "emotional."

Maiya expects to keep Lane in the hospital through the weekend to monitor her recovery.

ABC News' Russell Goldman contributed to this report.

Read More..

Military halts clashes as political crisis grips Egypt

CAIRO (Reuters) - Egypt's Republican Guard restored order around the presidential palace on Thursday after fierce overnight clashes killed seven people, but passions ran high in a struggle over the country's future.

The Islamist president, Mohamed Mursi, criticized by his opponents for his silence in the last few days, was due to address the nation later in the day, state television said.

Hundreds of his supporters who had camped out near the palace overnight withdrew before a mid-afternoon deadline set by the Republican Guard. Dozens of Mursi's foes remained, but were kept away by a barbed wire barricade guarded by tanks.

The military played a big role in removing President Hosni Mubarak during last year's popular revolt, taking over to manage a transitional period, but had stayed out of the latest crisis.

Mursi's Islamist partisans fought opposition protesters well into the early hours during dueling demonstrations over the president's decree on November 22 to expand his powers to help him push through a mostly Islamist-drafted constitution.

Officials said seven people had been killed and 350 wounded in the violence, for which each side blamed the other. Six of the dead were Mursi supporters, the Muslim Brotherhood said.

The street clashes reflected a deep political divide in the most populous Arab nation, where contrasting visions of Islamists and their liberal rivals have complicated a struggle to embed democracy after Mubarak's 30-year autocracy.

The United States, worried about the stability of an Arab partner which has a peace deal with Israel and which receives $1.3 billion a year in U.S. military aid, has urged dialogue.

The commander of the Republican Guard said deployment of tanks and troop carriers around the presidential palace was intended to separate the adversaries, not to repress them.

"The armed forces, and at the forefront of them the Republican Guard, will not be used as a tool to oppress the demonstrators," General Mohamed Zaki told the state news agency.

Hussein Abdel Ghani, spokesman of the opposition National Salvation Front, said more protests were planned, but not necessarily at the palace in Cairo's Heliopolis district.

"Our youth are leading us today and we decided to agree to whatever they want to do," he told Reuters.

UNITY APPEAL

Egypt plunged into renewed turmoil after Mursi issued his November 22 decree and an Islamist-dominated assembly hastily approved a new constitution to go to a referendum on December 15.

The Supreme Guide of the Brotherhood, to which Mursi belonged before he was narrowly elected president in June, appealed for unity. Divisions among Egyptians "only serve the nation's enemies", Mohamed Badie said in a statement.

Rival factions used rocks, petrol bombs and guns in the clashes around the presidential palace.

"We came here to support President Mursi and his decisions. He is the elected president of Egypt," said demonstrator Emad Abou Salem, 40. "He has legitimacy and nobody else does."

Opposition protester Ehab Nasser el-Din, 21, his head bandaged after being hit by a rock the day before, decried the Muslim Brotherhood's "grip on the country", which he said would only tighten if the new constitution is passed.

Another protester, Ahmed Abdel-Hakim, 23, accused the Brotherhood of "igniting the country in the name of religion".

Mursi's opponents accuse him of seeking to create a new "dictatorship". The president says his actions were necessary to prevent courts still full of judges appointed by Mubarak from derailing a constitution vital for Egypt's political transition.

Mursi has shown no sign of buckling under pressure from protesters, confident that the Islamists, who have dominated both elections since Mubarak was overthrown, can win the referendum and the parliamentary election to follow.

Mahmoud Hussein, the Brotherhood's secretary-general, said holding the plebiscite was the only way out of the crisis, dismissing the opposition as "remnants of the (Mubarak) regime, thugs and people working for foreign agendas".

As well as relying on his Brotherhood power base, Mursi may also tap into a popular yearning for stability and economic revival after almost two years of political turmoil.

The Egyptian pound sank on Thursday to its lowest level in eight years, after previously firming on hopes that a $4.8 billion IMF loan would stabilize the economy. The Egyptian stock market fell 4.4 percent after it opened.

Foreign exchange reserves fell by nearly $450 million to $15 billion in November, indicating that the Central Bank was still spending heavily to bolster the pound. The reserves stood at about $36 billion before the anti-Mubarak uprising.

(Additional reporting by Tom Perry and Yasmine Saleh; Writing by Alistair Lyon; Editing by Giles Elgood)

Read More..

All 13 Singaporeans on board stranded Indonesian ferry safe

SINGAPORE: All 13 Singaporeans on board a Singapore-Tanjong Pinang ferry which ran aground off Lobam island on Wednesday night are safe.

Ferry operator Sindo Ferry and Indonesia's Search and Rescue Agency, BASARNAS, gave this update in response to queries from Channel NewsAsia.

Of the 97 passengers, one Indonesian lady is still in hospital for medical attention.

The ferry, MV Sindo 31, left Singapore from Tanah Merah Ferry Terminal at 6.20pm on Wednesday.

At about 8pm, Sindo Ferry (formerly known as Penguin Ferry) received a call from the captain of the vessel that the ferry had ran aground off Lobam island.

The passengers and crew were stranded for around two hours.

Before help arrived, an Indonesian woman, accompanied by two family members were sent to a nearby hospital by local maritime police for urgent medical attention.

At about 10pm, two smaller local ferries, each with a capacity of 40 people, arrived to pick up the stranded passengers.

With combined efforts by the Tanjung Uban Sea and Coast Guards and BASARNAS, the passengers were ferried to Tanjung Uban, where they boarded a standby vessel , MV Penguin 7, and arrived at Tanjong Pinang near midnight.

The stranded ferry was not damaged and is currently moored at Tanjong Uban for further investigations.

Sindo Ferry says the stranded ferry is seaworthy and it is investigating the cause of the accident.

Weather conditions and low-tide are believed to have caused the accident.

- CNA/de

Read More..

Dhindsa’ election as IOA vice president hailed

SANGRUR: The controversies surrounding the elections of Indian Olympic association(IOA) in the wake of International Olympic committee(IOC) directing against it, the election of Punjab finance minister Parminder Singh Dhindsa as IOA vice president is being hailed in Punjab.

Dhindsa was elected as vice president in the election meeting held at New Delhi on Wednesday. Parminder' father and former union minister Sukhdev Singh Dhindsa had remained associated with IOA and is president of Punjab Olympic association since many years. Interestingly neighbouring Haryana has got the presidentship of IOA with Chautala Jr. bagging the post unopposed. Punjab deputy chief minister Sukhbir Singh Badal greeted Dhindsa on his election.

Parminder on his part as IOA vice president said "my first priority will be to get Kabaddi introduced in the national games and then make efforts to introduce the sport in Asian and Olympic Games".

Punjab Kabaddi association president Sikandar Singh Maluka expressed hope that now Kabaddi could easily be elevated at the national and the international platform.

Read More..

Celebrations planned as Wash. legalizes marijuana

SEATTLE (AP) — Legal marijuana possession becomes a reality under Washington state law on Thursday, and some people planned to celebrate the new law by breaking it.

Voters in Washington and Colorado last month made those the first states to decriminalize and regulate the recreational use of marijuana. Washington's law takes effect Thursday and allows adults to have up to an ounce of pot — but it bans public use of marijuana, which is punishable by a fine, just like drinking in public.

Nevertheless, some people planned to gather at 12:01 a.m. PST Thursday to smoke in public beneath Seattle's Space Needle. Others planned a midnight party outside the Seattle headquarters of Hempfest, the 21-year-old festival that attracts tens of thousands of pot fans every summer.

"This is a big day because all our lives we've been living under the iron curtain of prohibition," said Hempfest director Vivian McPeak. "The whole world sees that prohibition just took a body blow."

In another sweeping change for Washington, Gov. Chris Gregoire on Wednesday signed into law a measure that legalizes same-sex marriage. The state joins several others that allow gay and lesbian couples to wed.

That law also takes effect Thursday, when gay and lesbian couples can start picking up their wedding certificates and licenses at county auditors' offices. Those offices in King County, the state's largest and home to Seattle, and Thurston County, home to the state capital of Olympia, planned to open the earliest, at 12:01 a.m. Thursday, to start issuing marriage licenses. Because the state has a three-day waiting period, the earliest that weddings can take place is Sunday.

The Seattle Police Department provided this public marijuana use enforcement guidance to its officers via email Wednesday night: "Until further notice, officers shall not take any enforcement action — other than to issue a verbal warning — for a violation of Initiative 502."

Thanks to a 2003 law, marijuana enforcement remains the department's lowest priority. Even before I-502 passed on Nov. 6, police rarely busted people at Hempfest, despite widespread pot use, and the city attorney here doesn't prosecute people for having small amounts of marijuana.

Officers will be advising people to take their weed inside, police spokesman Jonah Spangenthal-Lee wrote on the SPD Blotter. "The police department believes that, under state law, you may responsibly get baked, order some pizzas and enjoy a 'Lord of the Rings' marathon in the privacy of your own home, if you want to."

Washington's new law decriminalizes possession of up to an ounce for those over 21, but for now selling marijuana remains illegal. I-502 gives the state a year to come up with a system of state-licensed growers, processors and retail stores, with the marijuana taxed 25 percent at each stage. Analysts have estimated that a legal pot market could bring Washington hundreds of millions of dollars a year in new tax revenue for schools, health care and basic government functions.

But marijuana remains illegal under federal law. That means federal agents can still arrest people for it, and it's banned from federal properties, including military bases and national parks.

The Justice Department has not said whether it will sue to try to block the regulatory schemes in Washington and Colorado from taking effect.

"The department's responsibility to enforce the Controlled Substances Act remains unchanged," said a statement issued Wednesday by the Seattle U.S. attorney's office. "Neither states nor the executive branch can nullify a statute passed by Congress" — a non-issue, since the measures passed in Washington and Colorado don't "nullify" federal law, which federal agents remain free to enforce.

The legal question is whether the establishment of a regulated marijuana market would "frustrate the purpose" of the federal pot prohibition, and many constitutional law scholars say it very likely would.

That leaves the political question of whether the administration wants to try to block the regulatory system, even though it would remain legal to possess up to an ounce of marijuana.

Colorado's measure, as far as decriminalizing possession goes, is set to take effect by Jan. 5. That state's regulatory scheme is due to be up and running by October 2013.

___(equals)

Johnson can be reached at https://twitter.com/GeneAPseattle

Read More..

Deadly, or Just Misused? Feds Sue Nap Nanny

The Consumer Product Safety Commission is taking action against the makers of a portable baby recliner called the Nap Nanny after five infant deaths linked to the product.

The commission filed a complaint Wednesday to force the manufacturer, Baby Matters LLC, to pull its product off store shelves and offer full refunds to their customers. In addition to the five deaths, the commission says there have been 70 complaints about children falling out of the Nap Nanny.

The commission says normally it can work things out with manufacturers to voluntarily recall a dangerous product, but for five months the makers of Nap Nanny have defiantly refused to pull its product or offer refunds.

"We believe it is a hazardous product and we are concerned about the safety of the children that are in there," Consumer Product Safety Commission spokesman Alex Flip told ABC News.

Baby Matters LLC describes the Nap Nanny as an infant recliner designed to increase the baby's comfort.

"We had to take action because of the number of incidences, and that is why we have filed this complaint against the company. They would not agree to a voluntary recall," Flip said.

The Nap Nanny was invented by a Philadelphia sportscaster and mother Leslie Gudel. She came up with the idea after learning her daughter would only fall asleep in the car seat.

New Findings on Breast Cancer Drug Tamoxifen Watch Video

Carbon Monoxide Leak Sickens School Children, Teachers Watch Video

In a statement posted on Nap Nanny's website, Gudel said she is heartbroken for the families who have lost a child, but says the victims' parents misused her product by either not strapping the baby in or placing the device on a table or in a crib.

Some of the cases involved recliners that were placed in a crib, which the company has urged parents not to do.

"We do not believe the complaint has merit and stand behind the safety of our product when used as instructed," Gudel wrote in the statement. "The Nap Nanny should be placed on the floor with the harness secured."

Gudel says that the ongoing battle with the CPSC has cost her company so much money that it was forced to close last month.

"Another small business is gone. Twenty-two Americans are out of work between Nap Nanny and our supplier. This doesn't take into account the financial impact our closure has had on our other U.S. suppliers," Gudel wrote.

The first infant death was reported in 2010, which caused Nap Nanny to recall the product that same year and raise the sides of the recliner. The manufacturer also posted warnings and made an instructional video for parents.

According to the complaint, in April 2010, a six-month old died when she suffocated while using the Generation Two Nap Nanny. The infant was not secured in the harness and the medical examiner ruled the cause of death was positional asphyxia.

In July 2010, a four-month old died when she suffocated between a Generation Two Nap Nanny and the bumper in her crib. This time, the infant was secured in the harness but it failed to adequately restrain her in the recliner.

Still, the maker of the Nap Nanny stands by their product and says they have gone to "great lengths to make the safest product possible."

"No infant using the Nap Nanny properly has ever suffered an injury requiring medical attention," Gudel said in the statement.

Some 5,000 Nap Nanny Generation One and 50,000 Generation Two models were sold between 2009 and early 2012. About 100,000 Chill models have been sold since January 2011, reports The Associated Press.

Read More..

Confrontation between rival protesters looms in Egypt crisis

CAIRO (Reuters) - Egypt's Muslim Brotherhood called for a rally backing President Mohamed Mursi outside his palace on Wednesday and leftists planned a counter-demonstration, raising fears of clashes in a crisis over a disputed push for a new constitution.

Mursi returned to work at his compound a day after it came under siege from opposition protesters furious at his drive to ratify a new constitution in a snap referendum set for December 15 after temporarily expanding his powers by decree.

The Islamist president said he acted to prevent courts still full of appointees from the era of autocratic predecessor Hosni Mubarak from derailing the draft constitution meant to complete a political transition in the Arab world's most populous state.

The Brotherhood, from which Mursi emerged to narrowly win a free election in June, summoned supporters to a demonstration outside the palace in response to what it termed "oppressive abuses" by opposition parties.

Brotherhood spokesman Mahmoud Ghozlan was quoted on its Facebook page as saying opposition groups "imagined they could shake legitimacy or impose their views by force".

Leftist opposition leader Hamdeen Sabahy promptly urged his supporters to go to the streets as well, heightening the chances of confrontation between Islamists and their opponents.

A spokeswoman for Sabahy's Popular Current movement asked protesters to head to the palace to reinforce those still camped out there after Tuesday evening's protests, in which officials said 35 protesters and 40 police were wounded.

Although they fired tear gas when protesters broke through barricades to reach the palace walls, riot police appeared to handle those disturbances with restraint.

About 200 protesters camped out overnight, blocking one gate to the palace in northern Cairo, but traffic was flowing normally and riot police had been withdrawn.

"Our demands to the president: retract the presidential decree and cancel the referendum on the constitution," read a placard hung by demonstrators on a palace gate.

The rest of the Egyptian capital was calm, despite the political furor over Mursi's November 22 decree handing himself wide powers and shielding his decisions from judicial oversight.

Crowds had gathered on Tuesday for what organizers dubbed a "last warning" to Mursi. "The people want the downfall of the regime," they chanted, roaring the signature slogan of last year's uprising that ousted Mubarak.

But the "last warning" may turn out to be one of the last gasps for a disparate opposition that has little chance of stopping next week's vote on a constitution drafted over six months and swiftly approved by an Islamist-dominated assembly.

MURSI STANDS HIS GROUND

Facing the gravest crisis of his six-month-old tenure, the Islamist president has shown no sign of buckling under pressure, confident that the Muslim Brotherhood and its Islamist allies can win the referendum and a parliamentary election to follow.

Many Egyptians yearn for an end to political upheaval that has scared off investors and tourists, damaging the economy.

Ahmed Kamel, spokesman for the Congress Party led by former Arab League chief Amr Moussa, said Mursi should meet opposition demands, not call for an Islamist counter-demonstration.

Some protesters have already gone beyond opposition calls for Mursi to scrap his decree, defer the referendum and set up a "representative committee" to revise the draft constitution, instead demanding the president's overthrow.

"The demands of the street are moving faster than those of the politicians," said Elijah Zarwan, a fellow with the European Council on Foreign Relations. "Now is the time for the Egyptian liberals to negotiate without conditions."

COURT PROTEST

Dozens of pro-Mursi demonstrators, watched by equal numbers of police, waved flags outside the Supreme Constitutional Court, whose rulings have complicated the Islamists' rise to power.

"You are not a political agency," read one banner held by the demonstrators, addressing a court that in June ordered the dissolution of the Islamist-led lower house of parliament.

Mursi issued his decree temporarily putting his actions above the law to forestall any court ruling to dissolve the upper house or the assembly that wrote the constitution.

State institutions, with the partial exception of the judiciary, have mostly fallen in behind Mursi.

The army, the power behind all previous Egyptian presidents in the republic's six-decade history, has gone back to barracks, having apparently lost its appetite to intervene in politics.

In a bold move, Mursi sacked Mohamed Hussein Tantawi, the Mubarak-era army commander and defense minister, in August and removed the sweeping powers that the military council which took over after Mubarak's fall had grabbed two months earlier.

The liberals, leftists, Christians, ex-Mubarak followers and others opposed to Mursi, elected in a close result against a secular rival, have yet to generate a mass movement or a grassroots political base to challenge the Brotherhood.

Protesters have scrawled "leave" over Mursi's palace walls, but the president has made clear he is not going anywhere.

"The crisis we have suffered for two weeks is on its way to an end, and very soon, God willing," Saad al-Katatni, head of the Brotherhood's Freedom and Justice Party, told Reuters.

Investors have seized on hopes that Egypt's turbulent transition, which has buffeted the economy for two years, may soon head for calmer waters, sending stocks 1.6 per cent higher after a 3.5 percent rally on Tuesday.

The most populous Arab nation has turned to the IMF for a $4.8 billion loan to help it out of a crisis that has depleted its foreign currency reserves.

The government said on Wednesday the process was on track and Egypt's request would go to the IMF board as expected.

(Additional reporting by Tom Perry and Yasmine Saleh; Writing by Alistair Lyon; Editing by Mark Heinrich)

Read More..

Singapore calls for emissions reductions to achieve climate change deal

DOHA: Singapore has called on countries to show their commitment by pledging emissions reductions in order to achieve a global deal on climate change.

Deputy Prime Minister Teo Chee Hean said the new agreement must be applicable to all.

"Climate change is a global challenge that requires a global solution. All parties have to play their part by making a contribution," he said.

Mr Teo was delivering Singapore's national statement at the High-Level Segment of the United Nations Climate Change Conference in Doha, Qatar, on Wednesday.

"In this regard, developed countries have to show leadership in emissions reductions. Developing countries, too, can and must make a contribution to the process," he said.

Mr Teo said for the new agreement to be applicable to all, it has to be acceptable to all. It has to take into account the unique national circumstances and constraints of parties.

He said this will allow each party to decide how best it can contribute, based on the context and constraints of each country, and provide a greater impetus for universal participation.

"The global agreement is only a means to an end. Ultimately, we need to encourage and incentivize all parties to adopt the right policies early to make the transition to a low emissions development pathway. It is therefore important to provide support to build capacity in developing countries," he said.

Mr Teo said Singapore is committed to play its part in the global fight against climate change.

He said Singapore has made an unconditional pledge to reduce its emissions by 7-11 per cent below business as usual (BAU) by 2020. It has also committed to a 16 per cent below BAU pledge, if there is a legally binding global agreement.

Mr Teo added: "Our vision for Singapore is a climate-resilient global city that is well-positioned for green growth. While climate change poses a challenge, it also offers tremendous opportunities for new economic growth. The global demand for low-carbon solutions will catalyse demand for new skills and technology.

"Singapore has placed priority on developing areas such as clean energy and energy efficiency, green buildings, public transport, smart grids, carbon management, as well as waste and water management.

"As Singapore is a city state with limited access to renewable energy, energy efficiency is core to our efforts to reduce emissions in all sectors. To support this, a new Energy Conservation Act will come into effect in April 2013."

Mr Teo said the global challenge of climate change requires a global response, with the participation of all countries and contributions by all.

"The multilateral rules-based system under the UNFCCC is fundamental to solving the global climate challenge. We need to protect and strengthen the UNFCCC and take it one step further towards a truly global agreement, so that it remains an important platform for global action against climate change," he said.

- CNA/de

Read More..

After DMK, UPA ally NCP says it is opposed to FDI in retail

NEW DELHI: Even as it voted in favour of FDI in retail, UPA's key constituent NCP today struck a discordant note by saying that it did not support implementation of the decision in Maharashtra.

"NCP does not support FDI in multi-brand retail," Patel, who is also the Union minister for heavy industry, told reporters outside Parliament soon after its members voted in favour of the move in the Lok Sabha.

He said the decision to implement FDI in retail in Maharashtra would be taken after consultations with its coalition partner Congress.

Earlier participating in the debate in the Lok Sabha, Patel sought to differ with telecom minister Kapil Sibal, who had yesterday said the Maharashtra government had spoken in favour of FDI in retail.

Noting that FDI would be implemented only in cities with population more than 10 lakh, he said "it is possible that this experiment may not succeed. If this does not work out, then be it (NCP chief) Sharad Pawar or myself we can revise our opinion.

"In Maharashtra, we have a coalition government (with Congress). Kapilji, yesterday you had said that Maharashtra government has favoured FDI in retail.

"But, I would like to make it clear on behalf of my party, I wish to state that there is a coordination committee (in the state). We will meet, discuss its merits and demerits and then decide on our party's stand which will be conveyed."

Yesterday, another key UPA constituent DMK had voiced its opposition to FDI in multi-brand retail.

DMK leader T K S Elangovan said the party was with the government because it had stated that FDI was the need of the hour to save the fiscal condition of the States.

Read More..

Longer tamoxifen use cuts breast cancer deaths

Breast cancer patients taking the drug tamoxifen can cut their chances of having the disease come back or kill them if they stay on the pills for 10 years instead of five years as doctors recommend now, a major study finds.

The results could change treatment, especially for younger women. The findings are a surprise because earlier research suggested that taking the hormone-blocking drug for longer than five years didn't help and might even be harmful.

In the new study, researchers found that women who took tamoxifen for 10 years lowered their risk of a recurrence by 25 percent and of dying of breast cancer by 29 percent compared to those who took the pills for just five years.

In absolute terms, continuing on tamoxifen kept three additional women out of every 100 from dying of breast cancer within five to 14 years from when their disease was diagnosed. When added to the benefit from the first five years of use, a decade of tamoxifen can cut breast cancer mortality in half during the second decade after diagnosis, researchers estimate.

Some women balk at taking a preventive drug for so long, but for those at high risk of a recurrence, "this will be a convincer that they should continue," said Dr. Peter Ravdin, director of the breast cancer program at the UT Health Science Center in San Antonio.

He reviewed results of the study, which was being presented Wednesday at a breast cancer conference in San Antonio and published by the British medical journal Lancet.

About 50,000 of the roughly 230,000 new cases of breast cancer in the United States each year occur in women before menopause. Most breast cancers are fueled by estrogen, and hormone blockers are known to cut the risk of recurrence in such cases.

Tamoxifen long was the top choice, but newer drugs called aromatase inhibitors — sold as Arimidex, Femara, Aromasin and in generic form — do the job with less risk of causing uterine cancer and other problems.

But the newer drugs don't work well before menopause. Even some women past menopause choose tamoxifen over the newer drugs, which cost more and have different side effects such as joint pain, bone loss and sexual problems.

The new study aimed to see whether over a very long time, longer treatment with tamoxifen could help.

Dr. Christina Davies of the University of Oxford in England and other researchers assigned 6,846 women who already had taken tamoxifen for five years to either stay on it or take dummy pills for another five years.

Researchers saw little difference in the groups five to nine years after diagnosis. But beyond that time, 15 percent of women who had stopped taking tamoxifen after five years had died of breast cancer versus 12 percent of those who took it for 10 years. Cancer had returned in 25 percent of women on the shorter treatment versus 21 percent of those treated longer.

Tamoxifen had some troubling side effects: Longer use nearly doubled the risk of endometrial cancer. But it rarely proved fatal, and there was no increased risk among premenopausal women in the study — the very group tamoxifen helps most.

"Overall the benefits of extended tamoxifen seemed to outweigh the risks substantially," Dr. Trevor Powles of the Cancer Centre London wrote in an editorial published with the study.

The study was sponsored by cancer research organizations in Britain and Europe, the United States Army, and AstraZeneca PLC, which makes Nolvadex, a brand of tamoxifen, which also is sold as a generic for 10 to 50 cents a day. Brand-name versions of the newer hormone blockers, aromatase inhibitors, are $300 or more per month, but generics are available for much less.

The results pose a quandary for breast cancer patients past menopause and those who become menopausal because of their treatment — the vast majority of cases. Previous studies found that starting on one of the newer hormone blockers led to fewer relapses than initial treatment with tamoxifen did.

Another study found that switching to one of the new drugs after five years of tamoxifen cut the risk of breast cancer recurrence nearly in half — more than what was seen in the new study of 10 years of tamoxifen.

"For postmenopausal women, the data still remain much stronger at this point for a switch to an aromatase inhibitor," said that study's leader, Dr. Paul Goss of Massachusetts General Hospital. He has been a paid speaker for a company that makes one of those drugs.

Women in his study have not been followed long enough to see whether switching cuts deaths from breast cancer, as 10 years of tamoxifen did. Results are expected in about a year.

The cancer conference is sponsored by the American Association for Cancer Research, Baylor College of Medicine and the UT Health Science Center.

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

Read More..